Why We’re Transitioning from NAD+ IV to Niagen® IV Therapy

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Niagen® IV Therapy is available at Evergreen Factor in Lake Oswego, Oregon — a physician-supervised NAD+ precursor infusion protocol using pharmaceutical-grade ChromaDex Niagen® (nicotinamide riboside chloride). Every session is evaluated, screened, and supervised by Dr. Tomas Gigena, M.D., a board-certified physician with over 28 years of clinical experience in integrative and cellular medicine.

This is not a wellness-lounge drip menu. It is a structured IV nutrient protocol administered inside a medical facility, under direct physician oversight, following clinical intake and safety screening.

• Location: 16555 Boones Ferry Rd #200, Lake Oswego, OR 97035
• Also serving: Silverton, Oregon (call for hours)
• Medical Director: Dr. Tomas Gigena, M.D.
• Session length: 45–60 minutes
• Pricing: Four Niagen tiers from $250 to $800
• Product: Pharmaceutical-grade ChromaDex Niagen® (FDA-registered 503B compounded)
• Booking: Clinical intake required. Call 1-844-433-2286 or email info@evergreenfactor.com

Interest in Niagen® IV has accelerated as patients learn that NAD+ — the coenzyme that powers cellular energy, DNA repair, and mitochondrial function — declines significantly with age. Research indicates that by age 50, cellular NAD+ levels may be reduced by approximately half compared to younger adulthood.

Patients in Lake Oswego, Portland, West Linn, Tigard, Tualatin, and across Clackamas County typically arrive at Niagen IV after one of three pathways:

1. They've heard about NAD+ IV therapy and are researching whether a precursor-based approach is more tolerable.
2. They've tried traditional NAD+ IV and found the 3–4 hour infusion time and side-effect profile (nausea, flushing, chest tightness) difficult to sustain.
3. They're exploring longevity, mitochondrial, or metabolic protocols and want a physician-supervised entry point rather than a med-spa drip.

Niagen IV Therapy at Evergreen Factor is designed for all three patient profiles, with dosing tier, session cadence, and integration with other protocols determined individually through clinical evaluation.

All tiers are administered under the direct supervision of Dr. Tomas Gigena, M.D., following clinical intake and medical screening. Dose selection is a clinical decision made during evaluation — tiers below are for reference, not self-selection.

Getting Started — $250

250mg Niagen® in 250ml Normal Saline. Introductory tier for patients new to NAD+ precursor IV protocols.

Next Level — $425

500mg Niagen® in 500ml Normal Saline. The most commonly prescribed maintenance dose.

Optimization — $650

750mg Niagen® in 1000ml Normal Saline. Intermediate protocol for patients cleared for advanced dosing.

Brain Reset — $800

1000mg Niagen® in 1000ml Normal Saline. Highest-dose tier, reserved for patients evaluated and cleared by Dr. Gigena for advanced protocol.

Member pricing for recurring sessions is available. Contact the clinic for details.

Niagen® is the pharmaceutical-grade, patented form of nicotinamide riboside (NR) produced by ChromaDex. NR is a vitamin B3 derivative that functions as a direct precursor in NAD+ biosynthesis — meaning the compound enters the cell and follows established enzymatic pathways (NRK1 and NRK2 phosphorylation) to generate NAD+ through the body's own salvage pathway.

Evergreen Factor uses authentic ChromaDex Niagen® — not generic NR compounds from unverified sources. For an intravenous application, sourcing, purity, sterility, and compounding standards are non-negotiable. Injectable Niagen® at Evergreen Factor is compounded through FDA-registered 503B outsourcing facilities.

Why the IV route is clinically distinct:

Oral NR supplementation is widely available and well-studied. Intravenous administration is selected when a clinical protocol requires bioavailability precision that oral formats cannot provide — bypassing gastrointestinal processing and first-pass hepatic metabolism, and delivering the compound directly into systemic circulation under controlled clinical conditions.

The decision between oral and IV administration, and the appropriate IV dosing tier, is made during clinical evaluation.

After treating hundreds of patients with traditional NAD+ IV therapy, I recognized that the standard protocol was working against many of the patients it was supposed to serve. A three-to-four-hour infusion accompanied by nausea, flushing, chest tightness, and headaches is not a healing experience — it is endurance. Many patients delayed or avoided follow-up sessions, which undermined the clinical value of the protocol itself.

Niagen® IV therapy, delivered as an NAD+ precursor rather than as pre-formed NAD+, allows a structurally different clinical experience: a 45 to 60 minute session that most patients find considerably more tolerable, while still supporting the body's NAD+ biosynthesis pathways. Traditional NAD+ IV therapy remains available at Evergreen Factor for patients who prefer it or for whom it is clinically indicated — but for most new patients, Niagen IV is now the protocol I recommend first.

Every Niagen IV session at our Lake Oswego clinic is supervised by me personally, or with me on-site or immediately on-call throughout treatment hours. — Dr. Tomas Gigena, M.D., Medical Director, Evergreen Factor

A common question from patients evaluating IV nutrient options is how Niagen® IV differs from direct NAD+ IV therapy, since both are offered at Evergreen Factor under Dr. Gigena's supervision.

The distinction is mechanistic:

• Direct NAD+ IV therapy delivers the fully formed NAD+ molecule (approximately 663 daltons) into circulation. Because of its size, much of the molecule is degraded by extracellular enzymes (CD38, CD73, CD203a) before reaching intracellular targets, which is part of why historical NAD+ IV protocols required long infusion times and high doses.
• Niagen® IV therapy delivers nicotinamide riboside (approximately 255 daltons, with lipophilic properties), which enters the cell and is converted through the NRK1/NRK2 enzymatic pathway into NMN and then NAD+ via the body's own salvage pathway.

Both protocols are clinically valid. Neither is universally superior. The correct choice is a clinical decision made during patient evaluation based on medical history, prior IV nutrient history, clinical objectives, and provider judgment.

Patients researching this distinction in greater depth can review the clinic's broader NAD+ therapy and clinical evidence resources.

Niagen IV Therapy is evaluated for patients in the Portland metro and Clackamas County area presenting with:

• Chronic fatigue patterns including CFS, ME/CFS, and post-viral fatigue, where mitochondrial support is a clinical consideration.

• Long COVID presentations with persistent fatigue, cognitive fog, or dysautonomia that has not responded to conventional rehabilitation. ClinicalTrials.gov identifier NCT04809974 is actively investigating NR in this population.

• Longevity and healthy aging focus, where DNA repair, metabolic flexibility, and cellular maintenance are priorities.

• Cognitive and executive performance patterns, including burnout and brain fog, where stimulant-based interventions are not a fit.

• Athletic recovery and training demands, where mitochondrial turnover and oxidative stress load are clinical considerations.

• Metabolic health patterns, including metabolic syndrome, prediabetes, and early type 2 diabetes.

• Family history of neurodegenerative disease, where neuroprotective research is a consideration during clinical discussion.

Candidacy is not determined by self-identification. Every new patient undergoes structured intake with Dr. Gigena, including medical history review, medication screening, contraindication evaluation, and baseline laboratory assessment when clinically indicated.

Niagen® has a well-documented safety profile supported by FDA GRAS status (2016) and NDI notifications (2015, 2018). Injectable Niagen® used at Evergreen Factor is compounded by FDA-registered 503B outsourcing facilities to pharmaceutical-grade purity and sterility standards.

Absolute contraindications (will not treat):

• Pregnancy and lactation (insufficient safety data)
• Severe renal impairment (fluid volume considerations)
• History of anaphylaxis to vitamin B compounds
• Active hemodynamic instability

Relative contraindications (require medical clearance before proceeding):

• Active cancer diagnosis (requires oncologist coordination)
• Severe hypotension or uncontrolled hypertension
• Concurrent antihypertensive medications
• Bleeding disorders or anticoagulant therapy
• History of severe vasovagal response to needle procedures

Potential drug interactions reviewed during screening:

• Antihypertensive medications
• Chemotherapy agents (theoretical interaction, oncologist approval required)
• Immunosuppressants
• Insulin and oral hypoglycemics

Emergency preparedness at the Lake Oswego facility:

• ACLS-certified staff on-site during all infusions
• Crash cart, defibrillator, and emergency medications maintained on-site
• Dr. Gigena on-site or immediately on-call during all treatment hours
• Direct referral relationships with Providence St. Vincent Medical Center and Legacy Meridian Park Medical Center for emergency transfer when indicated

Every patient completes a comprehensive medical history review, medication screening, and contraindication evaluation prior to initiating Niagen IV therapy.

• Arrival and check-in at the Lake Oswego clinic on Boones Ferry Road.
• Pre-infusion review — a brief clinical check-in before the protocol begins.
• IV placement and infusion over approximately 45–60 minutes in a private, monitored clinical setting.
• Post-infusion observation as clinically indicated before discharge.

The clinical environment is deliberately structured as a medical facility — not a wellness lounge. Patients are encouraged to hydrate normally before and after the session and to allow a buffer of unscheduled time after infusion rather than returning immediately to demanding activity.

For patients pursuing broader longevity, metabolic, or regenerative goals, Niagen IV can be integrated into multi-modality clinical plans under Dr. Gigena's supervision. Common combinations include:

• EBOO Therapy (Extracorporeal Blood Oxygenation and Ozonation) — for patients whose protocol includes oxidative and detoxification pathways alongside NAD+ precursor support.
• Red Light Therapy and PEMF — for patients whose protocol includes mitochondrial and cellular energy optimization pathways.
• High-Dose Vitamin C IV and Glutathione IV — for integrated antioxidant and redox protocols.

Combination protocols are never self-selected. Integration decisions are made by Dr. Gigena based on clinical presentation and patient-specific factors.

Evergreen Factor's IV Infusion Therapy facility is located in Lake Oswego, Oregon, and serves patients from across the Portland metropolitan region:

• Lake Oswego
• West Linn
• Tigard
• Tualatin
• Clackamas County
• Portland Metro (Westside)

Clinic Address: 16555 Boones Ferry Rd #200, Lake Oswego, OR 97035 The Lake Oswego facility is readily accessible from I-5 and Highway 217.

Hours (Lake Oswego):

• Monday: 7:00 AM – 5:00 PM
• Tuesday: 9:00 AM – 7:00 PM
• Wednesday: 7:00 AM – 5:00 PM
• Thursday: 9:00 AM – 7:00 PM
• Friday: 7:00 AM – 5:00 PM
• Saturday: 10:00 AM – 4:00 PM
• Sunday: Closed

Step 1: Call 1-844-433-2286 or email info@evergreenfactor.com to schedule clinical intake. 

Step 2: Complete medical history, medication review, and contraindication screening with Dr. Tomas Gigena, M.D. 

Step 3: Physician-directed Niagen IV dosing tier assigned based on clinical evaluation.

Step 4: Session scheduled at the Lake Oswego facility.

Niagen IV Therapy cannot be booked without clinical intake. This is a structural feature of the clinic's medical model, not an optional step.

How much does Niagen IV therapy cost in Lake Oswego?

Niagen IV pricing at Evergreen Factor ranges from $250 (250mg introductory tier) to $800 (1000mg highest tier). The most commonly prescribed tier is $425 (500mg). Tier selection is a clinical decision made during evaluation with Dr. Gigena.

Where can I get Niagen IV therapy near Portland, Oregon?

Niagen IV is available at Evergreen Factor's Lake Oswego clinic at 16555 Boones Ferry Rd #200, serving Portland, West Linn, Tigard, Tualatin, and the broader Clackamas County region. A secondary location is available in Silverton.

Is Niagen IV physician-supervised?

Yes. Every Niagen IV session at Evergreen Factor is evaluated, screened, and supervised by Dr. Tomas Gigena, M.D., a board-certified physician with over 28 years of clinical experience. Dr. Gigena is on-site or immediately on-call during all treatment hours.

How long does a Niagen IV session take?

Most Niagen IV sessions take approximately 45–60 minutes depending on dosing tier and individual clinical response.

What is the difference between NAD+ IV and Niagen IV?

NAD+ IV delivers the pre-formed NAD+ molecule directly into circulation. Niagen IV delivers nicotinamide riboside — a smaller precursor compound (approximately 255 daltons vs. 663 daltons) that cells convert to NAD+ through the body's own salvage pathway. Both are offered at Evergreen Factor; protocol selection is a clinical decision made during evaluation.

Is Niagen IV the same as generic NAD+ or B3 supplementation?

No. Niagen® is the patented, pharmaceutical-grade form of nicotinamide riboside produced by ChromaDex and studied in published human clinical research. It is distinct from generic B3, niacin, nicotinamide, or unbranded NR preparations.

How often do I need Niagen IV therapy?

Session cadence is determined by Dr. Gigena based on clinical presentation and protocol goals. Some patient profiles (e.g., post-viral fatigue, Long COVID) may involve weekly sessions over a defined period; maintenance protocols are typically less frequent. Cadence is not self-selected.

Can I switch from traditional NAD+ IV to Niagen IV immediately?

Most patients can transition at their next scheduled appointment without a washout period. Any switch is reviewed and authorized by Dr. Gigena during clinical check-in.

Does insurance cover Niagen IV therapy in Oregon?

IV nutrient therapy is generally considered elective wellness care and is not typically covered by insurance. Itemized receipts are available upon request. Contact your plan administrator directly for coverage questions.

Can I book Niagen IV therapy without a consultation?

No. All Niagen IV protocols at Evergreen Factor require clinical intake and physician-directed screening before administration.

Can Niagen IV be combined with EBOO or other therapies at Evergreen Factor?

Yes, for appropriate candidates. Dr. Gigena designs integrated, multi-modality protocols when clinically indicated. Combination decisions are not self-directed.

Evergreen Factor — IV Infusion Therapy

Medical Director: Dr. Tomas Gigena, M.D. 

Address: 16555 Boones Ferry Rd #200, Lake Oswego, OR 97035 

Call: 1-844-433-2286 

Email: info@evergreenfactor.comSilverton location also available — call for hours.

The information provided on this page is for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment recommendations. Nicotinamide riboside IV therapy is a medical procedure requiring physician evaluation and supervision. Individual responses vary based on health status, age, genetics, and adherence to protocol. Injectable Niagen® is compounded by FDA-registered 503B outsourcing facilities. Oral Niagen holds FDA NDI notifications (2015, 2018) and GRAS status (2016). Intravenous therapy carries inherent risks including infection, phlebitis, air embolism, and allergic reactions. Always consult with Dr. Tomas Gigena, M.D., or your qualified primary healthcare provider before beginning any new treatment — particularly if you are pregnant, nursing, have cardiovascular disease, diabetes, bleeding disorders, or take prescription medications. Statements regarding NAD+ precursors have not been evaluated by the FDA for specific disease treatment claims. Niagen IV therapy is not intended to diagnose, treat, cure, or prevent any disease.